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KMID : 0385920160270050473
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Journal of the Korean Society of Emergency Medicine
2016 Volume.27 No. 5 p.473 ~ p.481
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The Utility of the Optic Nerve Sheath Diameter in Predicting Post-Thrombolysis Intracranial Hemorrhage
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Jeon Gwang-Hoon
Kim Yang-Weon
Yoon Yoo-Sang
Kim Tae-Hoon
Park Deuk-Hyun
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Abstract
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Purpose: We tried to identify the factors associated with intracranial hemorrhage (ICH) in patients with acute brain infarction receiving a tissue plasminogen activator. We assumed that ICH is increased if intracranial pressure has been increased in brain infarction patients who underwent IV thrombolysis. In this study, we selected the optic nerve sheath diameter (ONSD) in a way that intracranial pressure (ICP) measurement. ONSD measurements were compared with the occurrence of brain hemorrhage.
Method: This study was a retrospective analysis of data acquired between January 2013 and December 2015. We included 100 acute brain infarction patients who received brain MRI and underwent IV thrombolysis in the emergency department. The ONSD measurements were taken with MRI in the axial view and compared with the occurrence of brain hemorrhage. The factors contributing to ICH in patients with thrombolysis was analyzed by a binary logistic regression analysis. Receiver operating characteristic (ROC) curves were used to find the cut-off value of ONSD that maximized the sum of the sensitivity and specificity. Statistical analysis was performed using SPSS 20.0.
Results: The mean ONSD for patients without ICH was 5.50±0.57 mm, and for those with ICH was 5.97±0.54 mm. ONSD in the ICH group were significantly larger than in the non-ICH group (5.50±0.57 versus 5.97±0.54).
Conclusion: ONSD in acute brain infarction patients who underwent IV thrombolysis is useful in the assessment of ICH risk.
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KEYWORD
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Brain infarction, Intracranial hemorrhage, Intracranial pressure, Optic nerve, Tissue plasminogen activator
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